Cystic fibrosis dating each other
This mucoid property predicts chronic infection that cannot be cleared.CF patients with have a decreased life expectancy of 30 years, compared with 40 years in non-colonized patients. It forms smooth fluorescent green colonies at 42o C, with a characteristic sweet (grape-like) odor, making it easy to recognize on solid media in the laboratory.As a group, pseudomonads have minimal nutritional requirements.The cystic fibrosis (CF) patient is not immunocompromised in the typical sense; the genetic defect is on chromosome 7, leading to the abnormal production of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein, consequently with malfunction of the chloride channel on the cell surface.Chronic airway infection is the most important cause of morbidity and mortality in cystic fibrosis, and the most significant pathogen in cystic fibrosis (28, 50).It can be found in fresh water environments (streams, lakes, and rivers), as well as sinks, showers, respiratory equipment, even contaminating distilled water (68).
This organism is a common opportunistic pathogen, leading to infections in patients with defects in host defenses, such as chronic neutropenias and defects of neurtrophil function, hematologic cancers, human immunodeficiency (HIV)/ acquired immunodeficiency syndrome (AIDS), and diabetes mellitus.
It can be found in large numbers on fresh fruits and vegetables.
Human colonization begins within the gastrointestinal tract, with subsequent spread to moist cutaneous sites such as the perineum and axilla.
They also experience a more rapid decline in pulmonary function and more frequent hospitalizations (72).
On the other hand, anti-Pseudomonal therapy that decreases sputum colonization is associated with improved pulmonary function and improvement in clinical scores (174) [See chapter on Cystic Fibrosis & bacteremia/ sepsis following procedures such as endoscopic retrograde cholangiopancreatography (ERCP), endoscopy, ophthtalmic devices, and transrectal ultrasound (TRUS) have been related to inadequate cleaning or disinfection of reusable medical devices. Respiratory therapy equipment and dialysis tubing, both of which require a wet, body-temperature environment, are particularly susceptible to contamination by colonization of the fingernails.